Desensitizing means of other groups, Symptomatic agents, Herbal remedies for phytoprophylaxis of allergy - Clinical pharmacology T.2

Desensitizing agents of other groups

Desensitizing agents include sodium thiosulfate, calcium glucopat, effective for allergic skin lesions.

Sodium thiosulfate is a complexing agent, usually used intravenously for poisoning with arsenic, mercury, lead, cyanide compounds. The drug may itself cause allergic reactions.

Calcium gluconate replenishes calcium deficiency, is used for hives, itching, itching dermatoses.

Inhibition of antibody production is achieved by immunosuppression: by administration of immunosuppressants (eg, glucocorticoids); antimetabolites (for example, blocking the synthesis of nucleic acids - mercaptopurine); alkylating substances involved in the destruction of nucleoproteins (eg, cyclophosphamide); cytotoxic antilymphocyte serum.

Induction of blocking effects mediated by antibodies is used in practice in the treatment of autoimmune diseases. For example, the preparation of monoclonal antibodies to the tumor necrosis factor-α (TNF-a)-infliximab (Remicade®), which neutralizes this pro-inflammatory cytokine, has proved effective in the treatment of rheumatoid arthritis, Crohn's disease, sarcoidosis. This mechanism also explains the clinical efficacy of immunoglobulin therapy in a wide range of autoimmune diseases, as well as antitoxic serum when bitten by poisonous animals.


In allergic bronchospasm, epinephrine, bronchodilators (xanthine derivatives, M-CL, β-AM) are effective. Local vasoconstrictors, imidazoline derivatives (oxymetazoline, xylometazoline, naphazoline, etc.) remove nasal edema in allergic rhinitis and relieve nasal breathing. In allergic rhinitis, combinations of H1 receptor antagonists with oral decongestants are often used. The algorithm for treating allergic rhinitis (year-round or seasonal) is shown in Fig. 8.12. Progressive therapy of an allergic rhinitis is presented in Fig. 8.13.

To reduce the effect of biologically active substances on cells and organs, sedatives are prescribed. This increases the resistance of the nervous system, contributes to reducing itching with hives.

Carrying out elimination measures is the most simple and safe way to prevent exacerbations and further progression of allergic diseases.

Non-drug therapies such as plasmapheresis, lymphocytosis, hemosorption, immunosorption, extracorporeal immunosorption, extracorporeal immunocorrection, contribute to the elimination of the allergen.

When allergic to a single allergen, allergen-specific immunotherapy (ASIT) is performed.

Herbal Remedies for Phytoprophylaxis of Allergy

Phytotherapy with pollen and cross allergies can cause exacerbations!

To plants with desensitizing properties include the turn and chamomile. Other plants effective for allergic diseases are listed below.

Labrador tea marsh ( Ledum palustre), the family. heather ( Ericaceae ). Indications: bronchial asthma, acute and chronic bronchitis, tracheitis, whooping cough, pneumonia, inflammation of the bladder and mucous membrane of the stomach, rheumatism, wet eczema.

Algorithm for the treatment of allergic rhinitis (year-round or seasonal)

Fig. 8.12. Algorithm for the treatment of allergic rhinitis (year-round or seasonal)

Progressive therapy of an allergic rhinitis

Fig. 8.13. Progressive therapy of an allergic rhinitis

Birch dangling ( Betula pendula), the family. birch ( Betulaceae ). Indication: eczema, urine acid diathesis, gallbladder inflammation, pustular skin diseases, edema.

Kaluga marsh ( Caltha palustris), the family. buttercup ( Ranunculaceae ). Indications: eczema, metabolic disorders, anemia, high cholesterol in the blood, neurodermatitis, rheumatism, long-term healing wounds.

Clover meadow ( Trifolium pratense), family. beans ( Leguminosae ). Indications: bronchial asthma, anemia, painful menstruation, inflammation of the bladder, bronchitis, dyspnea, prevention of atherosclerosis, burns, abscesses.

Scepter-like mullein ( Verbascum thapsiforme), family. ( Scrophulatiaceae ). Indications: bronchial asthma, liver and spleen diseases, bronchitis, hoarseness, sore throat, urolithiasis, gout, sciatica, joint disease.

Burdock large ( Arctium lappa), the family. Compositae ( Compositae ). Indications: eczema, inflammation of the kidneys, cholelithiasis and urolithiasis, diseases of the mucous membrane of the stomach and colon, itching of the skin, furuncles, long-healing wounds.

Daisy ( Bellisperennis ), the family. Compositae ( Compositae ). Indications: bronchial asthma, diseases of the mucous membrane of the urinary and gallbladder and liver ducts, internal bleeding, hemorrhoids.

Mistletoe white ( Viscum album), family. ( Loranthaceae ). Indications: bronchial asthma, atherosclerosis, inflammation of the kidneys, stomach, colon, neuralgia, trophic ulcers of limbs, whooping cough, uterine, pulmonary and nasal bleeding, muscle pains, bruises, fractures.

Walnut walnut ( Juglans regia), the family. nut ( Juglandaceae ). Indications: eczema, atherosclerosis, constipation, pulmonary hemorrhage, purulent rash, lichen, gastritis.

Common anthrax ( Aegopodium podagraria), family. umbrella ( Umbel-liferae ). Indications: exudative diathesis, inflammatory diseases of the kidneys and bladder, rheumatism, joint diseases, erysipelas and fungal skin lesions.

Pumpkin common ( Cucurbita pepo), the family. pumpkin ( Cucurbitaceae ). Indications: eczema, inflammation of the colon, kidneys, bladder, constipation, obesity, burns, helminthic invasion.

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