Biomedical instrumentation and measurement


SA node manages the speed of heart's muscular contractions which enables the center to circulate the blood throughout the body according to the need. Small variations in the heart beat are not damaging but in some cases due to malfunctioning of the heart's electric powered system, the heart rate varies drastically resulting in various types of arrhythmias. These cardiac arrhythmias are serious disorders that ought to be cured immediately. Arrhythmias like bradycardia (low heartrate) can be cared for using Pacemakers.

Pacemakers can be implanted in the patient's heart and soul for permanently revitalizing the heart and soul. It is utilized for patients for whom the SA node is no more functioning properly. Exterior Pacemakers are also available which is utilized to treat temporary heart rate variants. It is utilized for a short time frame prior to the implanting the inner Pacemakers in the heart and soul. To be able to understand the necessity of pacemakers, it's important to comprehend the functioning of the heart and its electronic system.


Heart is a pumping device which is utilized to circulate the bloodstream throughout the body. It has four chambers namely Right Atrium, Still left Atrium, Right Ventricle and Remaining Ventricle. The proper atrium receives the deoxygenated blood vessels from the complete body through the superior vena cava and substandard vena cava. The remaining atrium receives oxygenated bloodstream from the lungs through the pulmonary blood vessels. Once the atrium contracts the blood flows to the equivalent ventricle. That is credited to atrial depolarization. If the left ventricle contracts, the oxygenated blood is supplied to all tissues in the body through the aorta. That is credited to ventricular depolarization. Likewise, the deoxygenated bloodstream is pumped to the lungs for oxygenation through the pulmonary artery during the contraction of right ventricle. That is due to ventricular repolarization.

The Electrical conduction system of the heart includes SA node, AV node, Pack of His, Purkinje Fibers. The chambers of the center should be activated electrically for contraction. The stimulations are given by the SA node (Natural Pacemaker of the heart and soul) which is located in the right atrium of the heart and soul near the entrance of the superior vena cava. Although all the heart and soul cells have the ability to produce electric powered pulses which can encourage the center, SA node sets off the heart. The actual fact that SA node produces pulses at a higher rate in comparison with other potential cells which can promote contraction, plays a part in this phenomena. The contraction of various chambers of the heart and soul is characterized in an exceedingly specific manner. As the electric pulses pass through each chamber of the heart and soul, they are activated to deal. The SA node first triggers the right and kept atrium to contract. Then the impulses happen to be the AV node which is situated between your atria and the ventricles. From AV node, the pulses happen to be the pack of his. The pulses travel to the individual ventricles through the right and remaining pack branch and reach the Purkinje materials. In case the SA node fails, then your AV node acts as the primary pacemaker. When the AV node fails, then the Purkinje fibers takes the responsibility. The SA node will get blood supply from right and remaining coronary arteries. Under ischaemic conditions, the fatality of the afflicted cells will stop the SA node from triggering the pulse.

There is a time frame following the excitement of center muscle during which no other action potential can result in the center muscles. This era is recognized as Total or Effective Refractory Period (ERP) of heart. It is normally around 0. 4 sec. ERP is managed up to possible in order to maintain tachycardia also to coordinate the muscle contraction. The anti-arrhythmic drugs used by the patients usually prolongs the ERP.



The electronic activity of the heart muscles is saved as Electrocardiogram (ECG). It can be obtained non-invasively from the top of body by pursuing specific lead configurations. The electrical current made in the heart and soul scheduled to depolarization and repolarization is disperse not only within the heart but also throughout the body. So, ECG can be easily bought from the top of body through electrodes. ECG has four basic components specifically, P influx, QRS complex, T wave and U influx. P wave occurs during atrial contraction scheduled to atrial depolarization. The length of time of the P wave runs from 0. 08- 0. 1 sec. During the atrial depolarization, the impulse from the SA node spreads throughout the atrium. The period of time between the onset of the P influx and the start of the QRS organic is about 0. 12- 0. 2 sec. During the zero potential period between your P influx and QRS complex, the impulse journeys within the AV node and the Pack of His. QRS complex occurs during ventricular contraction credited to ventricular depolarization. The length of the QRS intricate amounts from 0. 06-0. 1 sec. T wave occurs during ventricular leisure credited to ventricular repolarization. Sometimes, a little positive U wave occurs following a T wave because of the last remnants of the ventricular repolarization.



Normal ECG:


Heart rateis nothing but the quantity ofheartbeatsper device oftimewhich is expressed as beats per minute (bpm) - which can vary as the body's need for air changes, such as duringexercise or sleeping. The measurement of heart rate can be used bymedical professionalsto help out with thediagnosisand traffic monitoring of medical ailments. Additionally it is utilized by individuals, such asathletes, who are thinking about monitoring their heart rate to get maximum efficiency of their training.

TheR waveto R wave interval(RR interval) is the inverse of the heart rate, that is one divided by RR interval gives the heart rate. Typical healthy relaxing heartrate in men and women is 60-80 bpm which is described be normal heartrate, with rates below 60 bpm referred to asbradycardia and rates above 100 bpm described astachycardia.

Missed ECG:


This can be found when the R-R interval is double the actual R-R interval (for normal things). Heart and soul pulses misses at some intervals and will not follow the premature pulse.



This is a crucial reduction of heart rate and characterized by normally aimed abnormally huge P waves and normal PR period. Whenever the R-R period surpasses 1 sec the heart rate goes below 60 and the condition is referred to as Bradychardia. There are three types of Bradychardia conditions based on the characteristics of the ECG influx, these are Sinus bradychardia, Atrio-ventricular nodal bradychardia and ventricular bradychardia respectively. They are really reviewed below.

Sinus bradycardia:


Sinus bradycardias are also called as Atrial bradychardias. This bradychardia condition is usually found in young and healthy men and women. The symptoms represent with the individual'srespirations. Theabnormalpattern of eachinhalationcorresponds with the heartrate decreasing. Expirationcauses an increase in the heart's rate of contraction. This is thought to be induced by changes in the vagal tone duringrespiration.

Sinus bradycardia is a sinus tempo of significantly less than 60 bpm. It is the condition within both healthy individuals and the ones who are believed wellconditioned athletes. The explanation for this is the fact their center muscle has become conditioned to have a higher stroke level and therefore requires fewer contractions to circulate the same level of blood.

Sick sinus syndromecovers conditions including severe sinus bradycardia, sinoatrial block, sinus arrest, and bradycardi-tachycardia syndrome (atrial fibrillation, flutter, and paroxysmal supraventricular tachycardia).

Atrio ventricular nodal bradycardia:


An atrio ventricular nodal bradycardia or AV junction tempo is usually induced by the absence of the electro-mechanical impulse from thesinus node. This usually appear on anEKGwith a standard QRS complexaccompanied with an inverted P influx either before, during, or following the QRS organic.

An AV junctional break free is a postponed heartbeat originating from anectopicfocus someplace in theAV junction. It occurs when the rate ofdepolarizationof the SA node comes below the rate of the AV node. This dysrhythmia also may occur when the electric impulses from the SA node fail to reach the AV node because of SA or AV stop. This is a protective mechanism for the heart and soul, to pay for a SA node that is no more handling the rate making activity, and is also one of a series of backup sites that can take over pacemaker function when the SA node does not do so. This would present with a longerPR interval. A junctional escape complex is a normal response which could result from excessive vagal tone on the SA node. Pathological triggers include sinus bradycardia, sinus arrest, sinus exit block, or AV stop.

Ventricular bradycardia:


This picture shows an ECG of any person with an unnatural rhythm (arrhythmia) named an atrioventricular (AV) stop. P waves show that the very best of the heart received electrical power activity. Each P influx is usually followed by the high (QRS) waves. QRS waves represent the electro-mechanical activity that causes the heart and soul to contract. When a P wave exists and not accompanied by a QRS influx (and center contraction), there is an atrioventricular block, and an extremely slow-moving pulse (bradycardia).


More than 60% people show up victim to center attacks in the majority of the countries around the globe each year and thousands more are critically damaged in accidents. Caring for these patients in special treatment units will involve the usage of specialized tools like pacemakers over the other important ones.

In the past few years electronic digital pacemaker systems have become quite one in saving lives of cardiac patients whose normal pacing functions have been impaired. With regards to the exact nature of any cardiac dysfunction, an individual may require short-term artificial pacing during the course of treatment or long lasting pacing to be able to lead an active, successful life after treatment.

A device with the capacity of generating unnatural pacing impulses and delivering those to the heart is known as a pacemaker system (commonly called a pacemaker) and consists of a pulse generator and appropriate electrodes. Pacemakers can be purchased in a number of forms. These are mainly divided into two types External pacemakers and Internal pacemakers respectively.


External pacemakers are used on the patients with temporary heart and soul irregularities, such as those came across in the coronary patient, including heart and soul blocks. Also, they are used for momentary management of certain arrhythmias that occur in the patients during critical postoperative periods and in the patients during cardiac surgery, especially if the surgery consists of the ideals or septum. An external pacemaker usually involves an externally worn pulse generator linked to electrodes located on or within the myocardium. External pacemakers, such as all sorts of pulse generators located beyond your body, are usually connected through wires introduced into the right ventricle with a catheter catheter. The pulse generator may be strapped to the lower arm of an individual who is restricted to bed, or worn at the midsection associated with an ambulatory patient.

We have made the pacemaker which is often divided into two general categories namely

  1. Asynchronous pacemaker &
  2. Synchronous pacemaker


This type of pacemaker is supposed for patients having long term heart blocks. The pace is preset. It can be varied externally within the number of 60 PPM to 180 PPM. Since this pacemaker functions whatever the patient's natural center tempo it poses a potential danger because of competition between the patient's rhythm and this of the pacemaker.



In patients who've normal center function the majority of the time, asynchronous pacing can be hugely dangerous, working against their own physiological pacemaker with the danger of rousing in the vulnerable amount of the T wave, a problem that can bring about fibrillation. The demand pacemaker includes an ECG amplifier and a typical pacemaker output pulse circuit that is modified to allow productivity from the ECG amplifier to inhibit the pulse generator. This pacemaker senses R-waves and its own timing and logic circuits matter out an elapsed time interval pursuing an R-wave or previously induced pulse. In the event the intrinsic R-wave does not appear prior to the elapsed time period, the ventricle is stimulated. If an R-wave is received, the counter-top is reset again. This sort of pacemaker is used for patients with bradycardia, and it ensures a heartbeat no slower than its collection rate.



Internal pacemaker are implanted within the pulse generator placed in a surgically developed pocket below the right or still left clavicle, in the left subcostal area, or in women, under the still left or right major pectoralis muscle. Internal leads hook up to electrodes that directly contact the within of the right ventricle or the surface of the myocardium. The precise located area of the pulse generator is dependent primarily on the sort of the electrode used, he dynamics of the cardiac dysfunction, and the method (mode) of pacing that may be prescribed. Since there are no external connections for making use of power, the pulse generator must be completely self comprised, with a electricity source with the capacity of continuously operating the machine for an interval of years.


A wide selection of electrodes may be used to evaluate bio electric occasions but almost all can be categorised as owned by one of three basic types;

  1. Micro electrodes
  2. Skin surface electrodes
  3. Needle electrodes

All three types of bio potential electrodes possess the metal-electrolyte interface. In each case, an electrode potential is developed over the software, proportional to the exchange of ions to the metal and the electrolytes of your body.


They are being used to assess bio electric potentials near or within a single cell. Microelectrodes are electrodes with tips sufficiently small to penetrate a single cell in order to acquire readings from within the cell. The end must be small enough to permit penetration without damaging the cell. This action is usually complicated by the difficulty of accurately placing an electrode with respect to a cell. Because of their small surface area, they have impedances well up into the megohms. For this reason, amplifiers with extremely high impedances are required to avoid loading the circuit and minimize the consequences of small changes in software impedance.


Skin surface electrodes are used to obtain bio electric potentials from the surface of the body. They are available in various size. Although any type of surface electrode can be used to sense ECG, EMG, EEG potentials, the larger electrodes are usually associated with ECG, since localization of the measurement is not important. Smaller electrodes are used in EEG and EMG measurements. Various types of disposable electrodes have been created lately to eliminate the requirement for cleaning and attention after each use. In general, disposable electrodes are of the floating type with simple snap connectors by which the leads, that are reusable, are fastened. Although, some disposable electrodes can be used again several times, their cost is usually low enough that cleaning for reuse is not warranted. They come pre gelled, ready for immediate use.


To reduce program impedance and, as a result, activity artifacts, some electroencephalographers use small subdermal needles to penetrate the scalp for EEG measurements. They are also used to measure EMG potentials from a particular band of muscles. They are really less vunerable to movement artifacts in comparison to surface electrodes as they create an software under the surface of the skin. By making direct contact with the subdermal tissues or the intercellular liquids, these electrodes also appear to own lower impedances than surface electrodes of similar interface area. Even though needle electrodes have less motion artifacts, surface electrodes are used to acquire ECG because surface electrodes are far more convenient for the patient. Most of the surface electrodes are cheap and reusable.


ECG sensors measure the time-varying magnitude of electric fields emanating from the heart. ECG worth are assessed by positioning non-invasive electrodes at the top of patient's skin. For the 3-business lead ECG sensor, the electrodes need to be positioned in a triangle (Einthoven Triangle) on the patient's upper body as shown in the physique 11. Each corner of the triangle corresponds to 1 of the limbs: right hands, left hand, remaining foot. With the bipolar system, one limb is linked to the positive terminal of the amplifier and another limb to its negative terminal. Three limbs (right arm-RA, still left arm-LA and still left leg/foot-LL) are used. The right lower leg was used as "earth", to minimize interference.


Bioelectric indicators have very high input impedance. To stop the transmission attenuation, we use Instrumentation Amplifier (Advertising 624) which also has high input impedance. It should have high gain and low end result impedance. To be able to take away the common mode signals, it should have a high Common Method Rejection Percentage (CMRR around 90 dB). The at the surface of the body amounts from 0 - 10 mV therefore the amplifier must have high gain (1000). We use a differential amplifier to amplify the bioelectric signals that happen as a potential difference between two electrodes, the bioelectric impulses are applied between the inverting and non-inverting inputs of the amplifier. The transmission is therefore amplified by the differential gain of the amplifier. For the disturbance indication, however, both inputs seem as though these people were connected jointly to a standard input source. Thus, the common mode interference sign is amplified only by the much smaller common method gain. The electrode impedances form a voltage divider with the suggestions impedance of the differential amplifier. If the electrode impedances aren't identical, the interference impulses at the inverting and non-inverting inputs of the differential amplifier may vary, and the desired degree of cancellation does not take place. Because, the electrode impedances can't ever be produced exactly identical, the high common setting rejection ratio of your differential amplifier can only just be realized if the amplifier comes with an input impedance higher than the impedance of the electrodes to which it is connected. There are different lead configurations such as 3-Lead, 5-Lead, 12-Lead for acquiring ECG Indication. We have used 3-Lead system Lead - I Construction.




LabVIEW (brief for Laboratory Virtual Instrumentation Executive Workbench) is a program and development environment for Aesthetic Programming Language from National Tools. LabVIEW is a graphical programming environment employed by millions of designers and scientists to develop sophisticated measurement, test, and control systems using intuitive visual icons and wires that resemble a flowchart.

LabVIEW offers unrivaled integration with thousands of hardware devices and provides hundreds of built-in libraries for advanced examination and data visualization. The LabVIEW system is scalable across multiple targets and operating systems. LABVIEW is a GUI (Graphical INTERFACE) that can be used for handling of indicators, images and other kinds of data. One of the most powerful features LabVIEW offers designers and experts is its visual encoding environment.

With LabVIEW, you can design custom virtual instruments by setting up a graphical user interface on the computer screen through which one can
  • Operate the instrumentation program
  • Control picked hardware
  • Analyze attained data
  • Display results

One can modify front panels with knobs, keys, dials, and graphs to emulate control panels of traditional devices, create custom test panels, or visually stand for the control and operation of processes. The similarity between standard movement charts and graphical programs shortens the training curve associated with traditional, text-based languages.

The behavior of the electronic equipment can be dependant on connecting icons mutually to create block diagrams, which are natural design notations for scientists and technical engineers. With graphical development, one can develop systems quicker than with standard programming dialects, while retaining the energy and flexibility had a need to create a variety of applications.

We have used Lab view to obtain the indication, filtering and do other handling of the ECG indication. The true time indication is given into as insight to ELVIS I which functions as the DAQ (data acquisition system). The stop diagram of the Laboratory view implementation is as shown in shape 14.


  • The ECG sign from the amplifier (using Advertisement 624) is given as input to DAQ for acquiring the signal in Lab view software.
  • FFT of the ECG signal is obtained and seen. We can start to see the rate of recurrence content of the ECG signal from the FFT obtained. WE can also start to see the existence of 50 Hz electric power line disturbance in the FFT of organic ECG.
  • A Smoothing filtration system with following features - Moving average, Rectangular filtration system with a 50 percent width of 20 is produced. The Smoothened ECG is viewed. Smoothing Filter is employed to remove sound and 50 Hz electric power line interference.
  • The Smoothened transmission is given as type to the Butterworth Strap Pass Filtration of order 2 and a low cutoff consistency of 5Hz and high cut off frequency of 15Hz. Band Pass Filter can be used to split up the QRS organic from the ECG Transmission.
  • The outcome of the Band Pass Filtration system is differentiated and squared inorder to improve the QRS organic from the remaining portion of the waveform.
  • The heart rate is computed using timing and firmness measurement stop. The block provides rate of recurrence of repetition of the QRS organic. The rate of recurrence value is converted into time value by firmly taking inverse than it. Heartrate is calculated the following.
  • Heart Rate = 60/R-R Interval


    R-R Period = 760ms

    Heart Rate = 60/760ms

    = 78. 94 Beats /Minute

  • If the calculated heartrate is below the normal value, then pacing pulses are produced. This is done by by using a case framework.
  • The case composition turns on only when the case holds true (Heart Rate is below normal value). In the case structure we've a square wave generator. The productivity of the square influx generator is differentiated and squared. We get a pulse therefore of these operations.
  • The rate and amplitude at which the pulses are produced can be customized easily at run time using settings.
  • Whenever the heartrate is normal, Fake condition is preferred.
  • For incorrect condition, we establish the amplitude and frequency of the rectangular influx as zero so that the pacemaker is switched off.
  • The Pacing Pulses made may also be taken out as an analog voltage from the ELVIS and can be viewed in a DSO. Only voltages in the range +10 volts to -10 volts can be studied out from LABVIEW through ELVIS.




We have executed the case framework and other blocks by studying the general lessons given in LV Fundamentals 1 MANUAL and LABVIEWBASICSII_85_ENG CLAD.

HARDWARE Execution:



The amplifier which is used in software implementation (Advertising 624) is also used here. It really is accompanied by a filtration. The amplifier output is just about 550 mV. A Filtration is a circuit that is identified to complete a specified band of frequencies while attenuating all alerts outside this music group. Filter networks may be either productive or unaggressive. Passive filter sites contain only resistors, inductors and capacitors. Effective filters use transistors or op amps plus resistors, inductors and capacitors. Inductors tend to be used in lively filters, because they're huge and costly and may have large interior resistive components. Band Pass Filters forward only a music group of frequencies while attenuating all frequencies outside the band. A straightforward high pass filtration system followed by a minimal pass filter will form a group pass filter. We've used a group pass filtration (0. 5Hz - 40 Hz) to eliminate high frequency indicators like EMG and low frequency components like Platform Collection Wandering and action artifacts. We've used another order Butterworth Filtration with -40 db/ten years roll-off.

For Low Cross Filtration, we used 0. 5 Hz as the cut off rate of recurrence. C1 is chosen as a convenient value between 100 pF and 0. 1F. For High Cross Filter, we used 40 Hz as the take off frequency. We have implemented a Group Pass Filter based on the design given in OPERATIONAL AMPLIFIERS AND LINEAR INTEGRATIONAL CIRCUITS.


NOTCH Filtration system:

A Notch Filtration system transmits frequencies in the forward group and rejects undesired frequencies in the stop strap. In applications where low level signals must be amplified, there may be present one or more of a variety of unwanted noise signs. Illustrations are 50, 60 0r 400 Hz frequencies from vitality lines, 120 Hz ripple from full - wave rectifiers, or even higher frequencies from controlled turning - type power items or clock oscillators. If both signals and signal regularity noise part are handed down through a notch filtration system, only the required signals will leave from the filter. The noise consistency is "notched out". We've designed a effective notch filtration system (using LM 324) to remove 50 Hz Power Line Disturbance. The amplitude of the acquired ECG signal is around 1 - 2 V. We acquired sound - free ECG for real-time signal acquisition as shown below.




In order to draw out the QRS Organic from the ECG indication obtained, we use a strap go away filter with center rate of recurrence of 17 Hz and band width of 6 Hz. The QRS signal extracted from the band pass filtration system is rectified for evaluating with the threshold voltage produced by the diagnosis circuit. The filtered and rectified ECG is stored on a capacitor. This filtered and rectified ECG is weighed against the fraction of the voltage. Whenever a threshold voltage is exceeded, the QRS pulse is recognized. After the recognition of each QRS pulse, the capacitor recharges to a new threshold value after every pulse.



Monostable Multivibrator creates a single output pulse in response to a input signal. Additionally it is known as One Shot Multivibrator. The period of time of the end result pulse will depend on only on the exterior components (resistors and capacitors) connected to the op-amp. The length of the source triggering pulse can be longer or shorter than the expected pulse. The duration of the result pulse is symbolized by the T. Since T can be evolved only by changing the resistors and capacitors, the one shot multivibrators can be considered as a pulse stretcher. This is because the width of the pulse can be much longer than the source pulse. In a well balanced or standby talk about, the end result of the multivibrator is zero or low-level reasoning. The end result of the multivibrator is pressured to go high (ЛVcc) when an external trigger is given. The result stays zero before next triggering pulse is given. Then your cycle repeats. The monostable multivibrator has only one stable talk about. Hence, the name monostable.

The QRS detector provides pulse for QRS detected which is given as an type trigger for a monostable multivibrator. This monostable multivibrator can be used to make a positive pulse (amplitude - 5V) of desired pulse width for every suggestions triggering (negative edge triggering) from the QRS detector. We had used 555 Timer as a monostable multivibrator.


Thus, the analog portion of the task gets over with multivibrator. The end result of the multivibrator is refined using PIC18F 4550 Microcontroller. It grades the beginning of the controller section.


PIC is a family group of Harvard architecture microcontrollers made by Microchip Technology, produced from the PIC1640 formerly developed by Basic Instrument's Microelectronics Section. The name PIC initially described "Programmable User interface Controller", but quickly thereafter was renamed "Programmable Intelligent Computer".

PICs are popular with developers and hobbyists likewise because of the low cost, huge availability, large user base, extensive assortment of application notes, availability of low cost or free development tools, and serial encoding (and re-programming with adobe flash memory) ability.

Like all Microchip PIC18 devices, PIC18F4550 family can be found as both standard and low-voltage devices. Standard devices with Enhanced Display memory, designated with an "F" in the part quantity (such as PIC18F4550), accommodate an operating VDD range of 4. 2V to 5. 5V. Low-voltage parts, selected by "LF" (such as PIC18LF4550), function over a protracted VDD range of 2. 0V to 5. 5V.

Our project runs on the standard PIC 18F4550. Hence this microcontroller runs on the flash program memory space of 24K bytes. It is a 8-bit microcontroller and so they manage data as 8-tad chunks. PICs have a set of registers that function as general purpose ram memory. Special purpose control registers for on-chip hardware resources are also mapped into the data space. The addressability of memory space varies depending on device series and in PIC 18F4550 external code ram is straight addressable which is an exceptional feature in comparison to baseline and middle line core devices.

PICs have a hardware call stack, which is employed to save go back addresses. The hardware stack is not software accessible on earlier devices, but this altered with the 18F4550 device. Hardware support for a general purpose parameter stack was lacking in early series, but this greatly increased in the 18F4550, making the this product architecture more friendly to advanced vocabulary compilers.

Core features

All of the devices in thePIC18F 455 series family add a selection of features that can significantly reduce electricity consumption during procedure. Key items include
  • Alternate Run Modes: By clocking the controller from the Timer1 source or the internal oscillator block, vitality use during code execution can be reduced by as much as 90%.
  • Multiple Idle Methods: The controller can also run using its CPU primary disabled however the peripherals still active. In these areas, power utilization can be reduced even more, to as little as 4% of normal operation requirements.
  • On-the-Fly Mode Switching: The power managed modes are invoked by customer code during operation, allowing the user to include power-saving ideas into their application's software design.
  • Low Consumption in Key Modules: The energy requirements for both Timer1 and the Watchdog Timer are reduced.

PIC18F 4550 has increased flash program memory space, high computational performance at an economical price. These features make these microcontrollers a rational choice for most high - performance, electricity delicate applications. It has an in built analog to digital converter. We have used MP Laboratory IDE, which is very reliable windows suitable software to program for PIC microcontrollers. It offers high level versatility for programming. It contains everything a programmer needs to write, edit, compile, website link and debug the microcontroller.



Each code developed is examined using PIC 18 Simulator IDE. The Simulator gives a great environment for the PIC microcontroller family. It gives all the required facilities to enable the machine designers to begin projects right from the nothing and complete them with ease and self confidence.

Many external inlayed buildind blocks can be simulated. A few of it's features are
  1. 8 x LED Mother board.
  2. Keyboard Matrix
  3. LCD Module
  4. Oscilloscope
  5. Signal Generator

Segment LED Screen Panel


The Code is encrypted in the controller using PIC Equipment 2. The coding for PIC microcontroller is comparable to C programming.

The microcontroller is the actual pacemaker of the job. We have used the microcontroller for creating pacing pulses in both synchronous and asynchronous function.


In asynchronous pacemaker the pacing pulses are produced at a predetermined rate, irrespective of the current heartrate. We've produced pacing pulses at three different rates (60, 70, 80). The amplitude of the pacing pulse can be fine-tuned from 0-5V utilizing a suitable potentiometer.

CONTROLLER Productivity FOR ASYNCHRONOUS Function(Pulse Rate 60, 70, 80)


In Synchronous mode operation, the Pacemaker produces the pacing pulses only once the SA node does not stimulate the heart and soul for confirmed time frame. After the SA node begins to promote the heart and soul normally, the performing of the synchronous pacemaker prevents. The output of the monostable multivibrator is directed at the microcontroller. The monostable multivibrator produces positive pulse for each and every ECG wave.

The microcontroller is utilized to monitor the time period between these pulses. Once the time period between any two pulses surpasses 1000 ms, the controller is designed to generate a rousing pulse. The Refractory period of the center muscles play a essential role here. If S A node produces a pulse immediately after 1000msec, it will not be considered by the heart and soul as a activation because it falls within the Effective Refractive Amount of the Center. The Heart muscles react to the stimulations only when appears after the Effective Refractive Period say 400msec. The time period between two square pulse is measured and can be used for heart rate calculation.


The heartrate is displayed using a Seven Segment Screen. The heartrate value obtained is changed into a BCD value. This BCD value is tapped from a 8-little bit slot of the microcontroller. The seven section display is manipulated by IC 4511. The BCD value obtained from the microcontroller is given as type to the IC 4511. We've used common cathode seven portion displays. The outcome of IC4511 to the related BCD inputs is really as shown in the table below.


Thus, we've successfully completed the program implementation of the task in LABVIEW. We have designed an asynchronous pacemaker. We've designed an ECG amplifier and the ECG transmission is converted into a square pulse for control in the microcontroller. We still have to work on the design of synchronous pacemaker.


This pin can be used to erase the storage locations inside the PIC (i. e. whenever we want to re-program it). In normal put it to use is linked to the positive resource rail.


These will be the resource pins VDD is the positive source and VSS is negative source, or 0v. The utmost source voltage is 6V and minimal voltage is 2V.

These pins are where we connect an exterior clock, which is crystal oscillator so the microcontroller has some type of timing.

Depending on the device selected and features enabled, there are up to five plug-ins available. Some pins of the I/O ports are multiplexed with an alternate function from the peripheral features on the device. In general, when a peripheral is allowed, that pin may not be used as an over-all purpose I/O pin. Each dock has three registers for its procedure. These registers are
  • TRIS register (data route register)
  • PORT register (reads the levels on the pins of the device)
  • LAT register (output latch)

The Data Latch register (LATA) is useful for readmodify- write businesses on the worthiness influenced by the I/O pins.


PORTA can be an 8-bit extensive, bi directional dock. The related data route register is TRISA. Arranging a TRISA bit (= 1) can make the equivalent PORTA pin an type (i. e. , place the corresponding output drivers in a high-impedance mode). Clearing a TRISA little (= 0) will make the related PORTA pin an end result (i. e. , place the items of the output latch on the selected pin). Reading the PORTA register reads the status of the pins; writing to it'll write to the interface latch.

The RA4 pin is multiplexed with the Timer0 component clock input to become the RA4/T0CKI pin. The RA6 pin is multiplexed with the key oscillator pin; it is allowed as an oscillator or I/O pin by selecting the primary oscillator in Settings Register 1H. You should definitely used as a interface pin, RA6 and its own associated TRIS and LAT parts are read as '0'. RA4 is also multiplexed with the USB module; it functions as a device input from an exterior USB transceiver.

Several PORTA pins are multiplexed with analog inputs, the analog VREF+ and VREF- inputs and the comparator voltage reference point output. The operation of pins RA5 and RA3:RA0 as A/D converter inputs is selected by clearing/placing the control bits in the ADCON1 register On the Power-on Reset, RA5 and RA3:RA0 are configured as analog inputs and read as '0'. RA4 is configured as an electronic input.


PORTB is an 8-bit large, bidirectional port. The related data direction register is TRISB. Establishing a TRISB bit (= 1) can make the corresponding PORTB pin an type (i. e. , put the corresponding output drivers in a high-impedance mode). Clearing a TRISB tad (= 0) will make the equivalent PORTB pin an outcome (i. e. , put the articles of the productivity latch on the determined pin).

Each of the PORTB pins has a poor internal pull-up. A single control bit can turn on all the pull-ups. This is performed by clearing little, RBPU.

On a Power-on Reset, RB4:RB0 are configured as analog inputs by default and read as '0'; RB7:RB5 are configured as digital inputs. Four of the PORTB pins (RB7:RB4) come with an interruption- change feature. Only pins configured as inputs can cause this interrupt that occurs. Any RB7:RB4 pin configured as an productivity is excluded from the interruption- change assessment. Pins, RB2 and RB3, are multiplexed with the USB peripheral and serve as the differential signal outputs for an external USB transceiver RB4 is multiplexed with CSSPP, the chip select function for the Streaming Parallel Port


PORTC is a 7-bit wide, bidirectional slot. The corresponding data route register is TRISC. Setting a TRISC bit (= 1) will make the matching PORTC pin an input (i. e. , place the corresponding output driver in a high-impedance method). Clearing a TRISC little (= 0) can make the corresponding PORTC pin an end result (i. e. , place the articles of the result latch on the preferred pin). In PIC18F4550 device, the RC3 pin is not carried out.

PORTC is generally multiplexed with serial communication modules, like the EUSART, MSSP component and the USB module Pins RC4 and RC5 are multiplexed with the USB module.

Unlike other PORTC pins, RC4 and RC5 don't have TRISC parts associated with them. As digital jacks, they can only work as digital inputs. When configured for USB operation, the data direction depends upon the configuration and status of the USB component at confirmed time.

On a Power-on Reset, these pins, except RC4 and RC5, are configured as digital inputs. To utilize pins RC4 and RC5 as digital inputs, the USB component must be disabled.


PORTD can be an 8-bit huge, bidirectional dock. The related data route register is TRISD. Setting a TRISD little bit (= 1) can make the related PORTD pin an suggestions (i. e. , put the corresponding output driver in a high-impedance mode). Clearing a TRISD little bit (= 0) will make the matching PORTD pin an output (i. e. , Put the contents of the productivity latch on the decided on pin).

Each of the PORTD pins has a poor internal pull-up. An individual control little bit, RDPU (PORTE<7>), can change on all the pull-ups. PORTD can also be configured as an 8-tad wide Streaming Parallel Port (SPP)


Code for Asynchronous Pacemaker:

Explanation of Functions used:

Delay 10KTCYx ( unsigned char int );

The notice x in the function name above stands for 'times' or 'multiplication'. It is not to be replaced by a number as done in other function titles.

Unit is a 8 little value in the range (0, 255). Device=0is equal to Unit =256.

TCY stands for 'instruction circuit'. The internal regularity of PIC 18 F4550 is 8 MHz.

  1. Leslie Cromwell, "Biomedical Instrumentation and measurement", Prentice hall of India, New Delhi, 2007.
  2. Joseph J. Carr and John M. Brown, "Launch to Biomedical Equipment Technology", Pearson Education, 2004.
  3. John G. Webster, "Medical Instrumentation Software and Design", John Wiley and sons, NY, 2004
  4. Principles of Biomedical Instrumentation and Way of measuring By Richard Aston
  5. Biomedical signal Evaluation ( A Case Study Approach)- Rangaraj. M. Rangayyan
  6. Digital Indication System-Level Design Using Laboratory VIEW BY Nasser kehtarnavaz and Namjin Kim
  7. LV Basics 1 Manual
  8. LabVIEWBasicsII_85_eng CLAD
  9. External Pacemaker- Jigar O Patel.
  10. Biomedical signal Examination (A Case Study Approach)- Rangaraj. M. Rangayyan.
  11. Operational Amplifiers and Linear Integrational Circuits - Robert F. Coughlin & Frederick F. Driscoll.
  12. Integrated Circuits - Roy Chowdry.
  13. PIC Microcontrollers -Know it all Di Jasio, Wilmshrust, Ibrahim, Morton, Bates, J. Smith, D. W. Smith, Hellebeyck.
  14. http://www. umm. edu/imagepages/1429. htm
  15. http://zone. ni. com/cms/images/devzone/tut/2007-07-09_141618. jpg
  16. http://ecee. colorado. edu/~ecen4618/lm324b. gif
  17. http://pfnicholls. com/consumer electronics/555_pinout. png

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